Hydrogen Peroxide Kills Cancer

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Ann Med. Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes. Can J Physiol Pharmacol. Hydrogen gas alleviates chronic intermittent hypoxia-induced renal injury through reducing iron overload. Increase in breath hydrogen concentration was correlated with the main pancreatic duct stenosis.

J Breath Res. Hydrogen cross-feeders of the human gastrointestinal tract. Gut Microbes. Biochem Biophys Res Commun. Estimation of the hydrogen concentration in rat tissue using an airtight tube following the administration of hydrogen via various routes. Hydrogen gas distribution in organs after inhalation: real-time monitoring of tissue hydrogen concentration in rat. Hyperbaric hydrogen therapy: a possible treatment for cancer.

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. Inadequate production of H 2 by gut microbiota and Parkinson disease. Trends Endocrinol Metab.

Inhalation of hydrogen gas elevates urinary 8-hydroxy-2'-deoxyguanine in Parkinson's disease. Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress. Am J Transl Res.

Sensor could help doctors select effective cancer therapy

PubMed Abstract Google Scholar. Hydrogen-rich saline attenuated subarachnoid hemorrhage-induced early brain injury in rats by suppressing inflammatory response: possible involvement of NF-kappaB pathway and NLRP3 inflammasome. Mol Neurobiol. Hydrogen gas attenuates myocardial ischemia reperfusion injury independent of postconditioning in rats by attenuating endoplasmic reticulum stress-induced autophagy.

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Cell Physiol Biochem. Inhibition of hepatic ischemic reperfusion injury using saline exposed to electron discharge in a rat model. Cell Med. Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model.

J Urol. Subcutaneous injection of hydrogen gas is a novel effective treatment for type 2 diabetes. J Diabetes Investig. Feasibility and safety of hydrogen gas inhalation for post-cardiac arrest syndrome- first-in-human pilot study. Circ J.

Supplementary files

Molecular hydrogen: a preventive and therapeutic medical gas for various diseases. Reactive oxygen species ROS homeostasis and redox regulation in cellular signaling. Cell Signal. Reactive oxygen species: a key constituent in cancer survival. Biomark Insights. Nita M, Grzybowski A. The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age-related ocular diseases and other pathologies of the anterior and posterior eye segments in adults. Oxid Med Cell Longev. ROS stress in cancer cells and therapeutic implications. Drug Resist Updat. Liou GY, Storz P.

Reactive oxygen species in cancer. Free Radic Res. Modulating ROS to overcome multidrug resistance in cancer.

Reactive oxygen species - Wikipedia

Mol Cancer. J Transl Med. Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov. Hydrogen gas alleviates oxygen toxicity by reducing hydroxyl radical levels in PC12 cells. Hydrogen gas alleviates the intestinal injury caused by severe sepsis in mice by increasing the expression of heme oxygenase The healing effect of hydrogen-rich water on acute radiation-induced skin injury in rats.

J Radiat Res. Preadministration of hydrogen-rich water protects against lipopolysaccharide-induced sepsis and attenuates liver injury. Protective effects of hydrogen gas against sepsis-induced acute lung injury via regulation of mitochondrial function and dynamics. Int Immunopharmacol. Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy.

Mol Clin Oncol. Local generation of hydrogen for enhanced photothermal therapy. Nat Commun. Immunity, inflammation and cancer: a leading role for adenosine. Nat Rev Cancer.

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Dermond O, Ruegg C. Inhibition of tumor angiogenesis by non-steroidal anti-inflammatory drugs: emerging mechanisms and therapeutic perspectives. Splicing regulation of pro-inflammatory cytokines and chemokines: at the interface of the neuroendocrine and immune systems. Aging, inflammation, and cancer.

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Nutrition, inflammation, and cancer. Nat Immunol. Plasma-derived inflammatory proteins predict oral squamous cell carcinoma.

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Front Oncol. Cytokine-induced modulation of colorectal cancer. Effects of hydrogen on polarization of macrophages and microglia in a stroke model. Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice. Asthma Res Pract. Int J Cancer. Association of proinflammatory cytokines and chemotherapy-associated cognitive impairment in breast cancer patients: a multi-centered, prospective, cohort study.

Ann Oncol. Chemotherapy-enhanced inflammation may lead to the failure of therapy and metastasis. Onco Targets Ther. Inflammation and pancreatic cancer: focus on metabolism, cytokines, and immunity. Consumption of hydrogen-rich water protects against ferric nitrilotriacetate-induced nephrotoxicity and early tumor promotional events in rats. Food Chem Toxicol. Huang D, Ichikawa K.

Drug discovery targeting apoptosis. Pfeffer CM, Singh A. Apoptosis: a target for anticancer therapy. Qiao L, Wong BC. Targeting apoptosis as an approach for gastrointestinal cancer therapy. Kumar S. Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more? Hydrogen-rich saline attenuates cardiac and hepatic injury in doxorubicin rat model by inhibiting inflammation and apoptosis.